In 1911 the Vincentian Fathers discontinued St. Vincent College and the college buildings became the home for St. Vincent Parish School. At the time, the school was located at Washington Boulevard and Grand Avenue.

In 1923, at the same time ground breaking began for a new parish church, a new school building opened. It was located on Flower and West Adams Street; one block east of what was to be the new church. In 1951 the state Highway Department proposed building the Harbor Freeway through the school area.

The existing school was built in four and a half months, establishing an all-time record for such a type of building. It was blessed in the late spring of 1954 by Cardinal McIntyre. In the spring of 1987, a new room was added to the school to house a computer lab.

St. Vincent Parish had more plans to expand, by adding a new building on the school grounds. The plans were to build the St. Vincent Center. The building opened in the spring of 1996. The USC sponsored Head Start was housed in the lower level of the St. Vincent Center “Esperanza Community Housing Corporation” is leasing space on the second floor.

In the winter of 1997 the school was the first in the Archdiocese of Los Angeles to adopt the computer program “Futurekids”, now EdTecTrain. In the summer of 2007, the USC sponsored Head Start relocated, providing much needed space for the school’s expansion. The relocation of the Kindergarten to the St. Vincent Center has provided space for a school library, office, and tutoring room on the second floor of the school.